ConclusionHFJV system can be utilized effectively in laryngopharyngeal and tracheal surgery, reducing intraoperative blood loss and increasing surgical industry of vision without apparent effects.ObjectiveThe function of this study was to Dopamine Receptor antagonist assess the mutation frequency of SLC26A4 gene in patients with enlarged vestibular aqueduct syndrome（EVAS） and/or Mondini dysplasia（MD）, so as to provide research for molecular analysis of deafness. MethodsIn total, 74 patients with sensorineural hearing reduction were one of them study. All patients underwent thin-layer CT study of temporal bone tissue. The coding exons of SLC26A4 had been analyzed by second-generation sequencing in most topics. ResultsAmong them, 37 customers with EVAS and MD（E+M group）, 28 patients with EVAS and without MD（E group）, and 9 clients with remote MD（M group） had been identified. In 74 cases, 66 cases（89.2%） had been discovered to possess mutation, including 64 cases（86.5%） of biallelic mutation as well as 2 cases（2.7%） of single allele mutation. The recognition rate of SLC26A4 in various teams ended up being statistically significant（P less then 0.001）. The mutation rate in group M had been notably reduced than that in Group E and E+M（P less then 0.001）. In Group E, 27 cases（96.4%） had SLC26A4 biallelic mutations and one case（3.6%） had SLC26A4 solitary allele mutation, correspondingly; in Group E+M, 37 cases（100%） had SLC26A4 biallelic mutations; in team M, only 1 patient（11.1%） carried monoallelic mutations associated with SLC26A4 gene. ConclusionThere are many different pathogenesis in Chinese EVAS patients with or without MD, or isolated MD. Early clinical hereditary analysis of customers with EVAS and/or MD helps to supply precise information on the genetic reasons for hearing loss, offer hereditary guidance, and apply proper infection Thai medicinal plants control and prevention actions. Next generation sequencing technology plays tremendously crucial role in molecular diagnosis of deafness.ObjectiveTo investigate the changes of serum B cellular activating factor（BAFF） levels in chronic rhinosinusitis with nasal polyps（CRSwNP） patients and its particular predictive value in phenotypes. MethodsForty healthy volunteers（control group） and 77 patients with CRSwNP were recruited in the present research, all CRSwNP clients had been split into eosinophilic（neCRSwNP group, n=40） and non-eosinophilic（eCRSwNP team, n=37） according to the amount of eosinophil infiltration in postoperative histological areas. Serum samples had been gathered from all subjects, and serum BAFF levels had been detected by ELISA, plus the relationships between BAFF amounts and medical factors were assessed. The predictive worth of serum BAFF in differentiating eCRSwNP ended up being evaluated by receiver operating curve（ROC） and Logistic regression. ResultsBAFF concentrations within the serum of CRSwNP customers were（1.2±0.4） ng/mL, that have been more than control group（[0.8±0.3]ng/mL）. In inclusion, serum BAFF levels in eCRSwNP group had been （1.3±0.5） ng/mL, which were higher than neCRSwNP group（[1.1±0.2]ng/mL）, and both teams had been more than control groupt（P less then 0.05）. The increased serum BAFF levels in CRSwNP clients were absolutely correlated using the tissue eosinophil percentage（r=0.629, P less then 0.001） and counts（r=0.563, P less then 0.001）, peripheral blood eosinophil percentage（r=0.411, P=0.002） and counts（r=0.501, P less then 0.001）, and serum complete IgE（r=0.178, P=0.021）. Multivariate Logistic regression showed that serum BAFF level was a completely independent factor connected with CRSwNP phenotypes（OR=3.652, P=0.001）. ROC analysis suggested that serum BAFF exhibited an excellent predictive worth for eCRSwNP（AUC=0.885）. ConclusionSerum BAFF levels were increased in CRSwNP customers and linked to the amount of systemic and polyp eosinophilic infection. Preoperative analysis of serum BAFF degree possibly medically important for differentiating CRSwNP phenotypes.ObjectiveStudy in the value of quantitative measurement of key structures of internal ear by high resolution computer tomography（HRCT） in hearing analysis of clients with congenital extreme sensorineural hearing loss（SNHL）. MethodsA total of 90 kids with acutely severe SNHL diagnosed and treated in Beilun District folks’s medical center from January 2018 to February 2021 had been collected since the experimental group. In identical period, 90 children（180 ears） with normal internal ear structure and hearing had been scanned because of head stress and suspected temporal bone tissue break. Logistic univariate and multivariate regression evaluation were utilized to assess the facets affecting the event of excessively severe SNHL. On the basis of the link between multivariate analysis, a Nomogram forecast model ended up being set up. The model before and after internal correction was assessed by the receiver working characteristic curve. ResultsInner ear malformation, SSCC bone tissue island width, LSCC bone tissue island width and cochlear level were separate risk facets for extremely extreme SNHL. The results of Nomogram predictive model revealed that cochlear height 34 things, LSCC bone island width 19 things, SSCC bone tissue medication knowledge area width 22 points, internal ear malformation 37 things, the total score（112 points） corresponding to the incidence of acutely extreme SNHL（0.3%）. The specific C-index value of Nomogram forecast model is 0.858, the C-index of inner verification is 0.851, in addition to C-index of outside confirmation is 0.847. The coincidence of the design is good. It is strongly recommended that the model can efficiently predict the chance aspects of congenital exceptionally severe SNHL and has high forecast precision. ConclusionThe standardized measurement of SSCC bone island width, LSCC bone tissue island width and cochlear height by HRCT is of great value into the diagnosis of microinner ear malformation in kids with excessively severe SNHL.ObjectiveTo analyze the clinical features and the prognostic aspects of early-stage external auditory canal carcinoma. MethodsData from 36 clients with early-stage additional auditory canal carcinoma（T1, T2） addressed in division of Otolaryngology, Xijing Hospital, Air power Military Medical University from January 2008 to June 2020 were assessed retrospectively, including clinical manifestations, medical and treatment options, pathological kinds and infection condition.